Benoit Chardon
Today, innovation in aesthetics is no longer cosmetic—it is biological, regenerative, and longevity‑driven.
Regenerative Injectables: When Biology Replaces Volume.
1. Tience — Human Biology, Healing Itself
Tience is revolutionary because what could be more efficient at healingl human tissue than a treatment of human origin. Tience is the only cell free, non-surgical, off-the-shelf product derived from human adipose tissue. Instead of fillers, synthetic particles, or inflammation-based stimulation, it activates the skin’s own intrinsic repair mechanisms by boosting collagen and elastin production, promoting hyaluronic acid synthesis, and supporting microcirculation. Tience is not closest to human; it is human. It helps the skin remember how to heal.
2. Prodermis — Rebuilding the Dermal Foundation
Prodermis treats skin architecture, not surface appearance.
By acting directly on the dermal matrix, Prodermis (combining cross-linked hyaluronic acid with polynucleotides) strengthens firmness and resilience at the structural level. It delivers discreet, durable improvement—exactly what sophisticated consumers now expect from injectables. We need to see a published clinical study to validate the safety & efficacy of this innovation.
3. Profhilo Structura — Regenerating Deep Fat, Not Skin
Profhilo Structura targets deep adipose tissue—the forgotten driver of facial aging. Unlike Tience and Prodermis, which act primarily on skin quality, Profhilo Structura focuses on restoring the deep fat compartments that underpin facial structure. It makes it uniquely complementary: together, these three redefine injectables as a full‑depth regenerative strategy.
Hair Growth: Precision Over Promises.
4. Mallia — Treating the Scalp as an Ecosystem
Mallia is innovative because it reframes hair loss as a biological scalp disorder, not a cosmetic problem. By addressing hair growth and follicular health, Mallia offers a science‑led alternative to transplants and camouflage—appealing to consumers seeking credibility and non‑invasive solutions.
5. Derma Gene — Molecular Accuracy for Hair Regrowth
Derma Gene is revolutionary because it applies DNA‑level precision to hair loss, without systemic exposure. Using topical DNAzyme technology, Derma Gene targets DHT signalling directly at the follicle. It delivers personalised, local efficacy—without the compromises of oral therapies.
Under‑Eye: Finally Treated as Its Own Zone.
6. Revanesse — Designed for the Tear Trough
Revanesse was applauded the IMCAS Innovation Award 2026 for respecting the under‑eye as a distinct anatomical and functional zone. Its precision reduces risk, improves predictability, and answers one of the biggest unmet needs in aesthetic medicine.
Longevity Skincare: Daily Biology, Not Cosmetic Ritual.
7. Skin Diligent — Pharmaceutical Discipline at Home
Skin Diligent is revolutionary because it frames skincare like a long-term biological care: regulate chronic stress and preserve barrier integrity – the biological ‘ground’ that determines resilience. Barrier disruption is known to trigger inflammatory signalling in skin, which adds to the overall inflammatory load. Skin Diligent further differentiates through pharma-like integrity testing, including reported screening of finished formulas for hormonal receptor disruption activity.
8. Rapalogix — Longevity Science Goes Topical
Rapalogix brings longevity biology into topical care by targeting mTOR-pathway signalling—one of the best-studied nodes in geroscience, with a TORC1-specific inhibitor, RLX-201. Importantly, topical mTOR inhibitors have human, placebo-controlled clinical evidence showing reductions in senescence/aging markers in skin, supporting the idea that the pathway can be modulated locally rather than merely masking surface signs. Rapalogix won First Place at IMCAS Innovation Tank 2026.
9. RoC 35 — Clinical Proof, At Scale
RoC 35 stands out thanks to one of the largest real‑world clinical skincare studies ever conducted: 200 patients, 35 clinics, 90 days, 5 skincare routines (Potent combination of proprietary Retinol, Vitamin C, THPE, HA, SPF). It proves that serious evidence and accessibility can coexist: patients report 9.6% skin rejuvenation after 3 months, backed by Visia medical imaging.
10. Epidarus — Preserving Hyaluronic Acid, Not Forcing It
Epidarus is innovative because it inhibits HA breakdown (especially hyaluronidase 1) to preserve high-molecular-weight HA and reduce pro-inflammatory low molecular weight fragments —safe, controlled, and preservative rather than stimulatory. It protects skin balance over time instead of artificially boosting HA production.
Together, these ten innovations signal a clear shift: aesthetics is no longer about adding, filling, or correcting. It is about regenerating, preserving, and optimising biology—beautifully, intelligently, and for the long term.
Benoit Chardon
A global expert in medical aesthetics and category‑creating innovations. Over the past two decades, Benoit has helped build, scale, and redefine some of the most transformative brands in the industry, from Filorga to CoolSculpting, from Skinboosters to Sculptra. Benoit is now a jury member for the IMCAS Innovation Awards and Chairman of AMWC Innovation Catalyst session. www.bchardonconsulting.com
