A true scientific breakthrough by DERMEDEN Laboratories – A new Protocol for Hyperpigmentation
The need to adapt protocols to skin types, added to the risk of post-inflammatory hyperpigmentation (PIH) induced by procedures, complicates the treatment. So, what is the solution?
Combining strong depigmenting ingredients with aesthetic procedures
DERMEDEN Laboratories created the MELAFLASH SET protocol, a complete professional treatment combining aesthetic procedures (microneedling, laser, etc.) with 4 highly dosed molecules (5% Tranexamic Acid, 10% Niacinamide, 8.5% Lactic Acid and 2% Ferulic Acid), with a Home treatment based on 20% encapsulated Glycolic Acid, 5% Tranexamic Acid, 6% encapsulated Retinoids and 10% Niacinamide. One set covers 1 professional session and 1 month of at-home treatment. It can be applied to all phototypes, with no limit for repetition.
The benefits of combining Tranexamic Acid with Niacinamide:
Tranexamic acid has a unique depigmenting action: it inhibits the plasminogen-plasmin pathway, reduces inflammatory mediators and limits the transfer of melanosomes. This makes it a particularly effective active ingredient against PIH, melasma, PHO or post-acneic hyperpigmentation, for which simple tyrosinase inhibition is not enough. Niacinamide also inhibits the transfer of melanosomes and has complementary anti-inflammatory and antioxidant effects. Together, they simultaneously target the production, transport and stabilisation of melanin, providing a synergistic and long-lasting depigmenting effect.
The DERMEDEN MELAFLASH Protocol:
3 professional sessions (1 per month) including a light depigmenting peel (3 layers per section, leave on for 5 mn, rinse), a sterile depigmentation concentrate to be combined with the procedure chosen by the doctor (microneedling, laser, etc.) and a post-act depigmentating mask (leave on 10 mn), all highly concentrated in Tranexamic Acid and Niacinamide (TXA 11.8%, NIA 13%). Then an at-home protocol to be renewed every month after the aesthetic procedure combining Glycolic Acid, Tranexamic Acid, and Niacinamide with Retinoids, all highly dosed.
Promising results:
A dermatologically controlled clinical study is currently underway to measure the synergies between professional and an at-home treatment (particularly in terms of rebound effect and reduction in pigmentation over time). Still, initial clinical results for the products are very encouraging (Tables 1 and 2).
For more information: www.DERMEDEN.com
