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  • Aesthetic Medicine
  • Polynucleotides

Polynucleotides: Optimising Skin Vitality

  • 27th January 2025
  • Thierry PIOLATTO

By Dr Linda Fouque

Thanks to their unique properties, Polynucleotides enhance hydration, tissue revitalisation, and skin regeneration.

Polynucleotides are true informational molecules, encoding specific cellular activities. This innovative treatment stimulates the skin’s natural physiological processes, promoting bioregeneration and boosting skin vitality. They represent a significant breakthrough in preserving and restoring the skin’s metabolic capabilities while ensuring exceptional tolerance and remarkable efficacy.

A Therapeutic Legacy for Aesthetic Applications

For over 30 years, Polynucleotides have been used in medicine for their wound-healing properties, particularly in treating burns and ulcers. Today, these molecules, derived from nucleotide fragments extracted from fish, have found promising applications in aesthetic dermatology. Their ability to hydrate, revitalise, and protect skin tissues makes them a key solution to address the needs of skin at various ages and in diverse conditions.

Restoring the skin’s natural abilities

Unlike superficial treatments that offer only temporary effects, Polynucleotides work in depth by stimulating the skin’s natural mechanisms. These informational molecules act as biological messengers, encoding specific cellular functions. They directly target the fibroblasts, essential cells for the synthesis of collagen and elastin—key elements for skin firmness and elasticity. Additionally, they promote angiogenesis, a process that enhances vascularisation, ensuring better nutrition and oxygenation of tissues. This dual action enables effective and long-lasting regeneration, optimising skin vitality.

Immediate and long-lasting results

Polynucleotides deliver immediate benefits through deep hydration, giving the skin a natural glow from the very first sessions. This glow effect is further enhanced by progressive tissue revitalisation, marked by increased collagen production and improved elastin fiber organisation. This physiological process, which respects the skin’s natural functions, involves minimal side effects, aside from occasional transient swelling. Over time, the skin becomes firmer, more toned, and more resilient to external aggressors.

A Treatment Suitable for All Skin Types

The Polynucleotides’ high tolerance makes them an ideal solution for all skin types, including the most sensitive. Unlike some injectable treatments, these molecules do not contain active proteins that could trigger immune reactions. This makes them particularly suitable for delicate areas such as the eye contour, neck, and décolleté. Polynucleotides also address the needs of mature skin by stimulating cell regeneration and improving microvascularisation.

A Versatile Tool for Various Aesthetic Needs

Whether preventing signs of aging, repairing damage caused by smoking, pollution, or excessive sun exposure, or revitalising weakened skin, Polynucleotides are a versatile solution. By promoting detoxification and cell regeneration, they effectively support patients in their pursuit of healthy, radiant skin. Their integration into personalised treatment protocols ensures visible results, meeting the diverse expectations of patients.

Enhanced Synergy with LED Photobiomodulation

Combining Polynucleotides with LED photobiomodulation sessions offers a distinct advantage in aesthetic treatments. Following each injection, LED lights further activate cellular regeneration mechanisms, optimising the results. This combination improves skin texture and uniformity while accelerating post-treatment recovery. Observed benefits include smoother, more hydrated, and visibly rejuvenated skin, with amplified effectiveness through this technological synergy.

This synergy is particularly impactful in treating alopecia, showing remarkable results in revitalising the scalp and regenerating hair follicles while stimulating the dermal cells responsible for hair growth. The combined treatment proves especially valuable for skin rehabilitation, boosting collagen and elastin production while optimising cellular metabolic functions.

Towards a Comprehensive Approach to Skin Regeneration

By incorporating Polynucleotides into comprehensive aesthetic care protocols, practitioners can address the growing demands of discerning clients. These molecules not only provide solutions for common aesthetic concerns but also contribute to preserving cellular youth. Their impact on skin homeostasis, combined with their ability to maintain fibroblast secretory activity, makes them an essential tool in supporting patients throughout their treatment journey.

Polynucleotides, with their unique ability to stimulate skin regeneration, represent a significant advancement in aesthetic dermatology. Hydrating, antioxidant, and revitalising, they improve skin structure and health. These treatments can be considered Regenerative Fillers, maintaining skin homeostasis and sustaining fibroblast secretory activity for long-lasting revitalised skin.

Dr Linda Fouque: Aesthetic dermatologist, Vice-President of the LED Academy, and founder
of the Healthy Skin concept. An international speaker and lecturer at the University of the Face and Neck, she is constantly pursuing the latest advancements in skin regeneration.

More informations: drfouquelinda.fr

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Thierry PIOLATTO

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