Valérie Orsoni
Aging is not merely a matter of years, genetics, or hormones. It is fundamentally inflammatory.
This diffuse, silent, persistent inflammation accelerates cellular decline without obvious clinical signs, yet it is rarely addressed at its root. Over the past fifteen years, the concept of inflammaging has progressively gained recognition in scientific research. It describes a state of chronic, lowgrade inflammation present from adulthood, capable of accelerating biological aging independently of overt disease. Unlike acute inflammation, which is essential for tissue repair, this form is persistent, silent, and harmful. It sustains continuous activation of molecular pathways such as NF-κB, increases pro-inflammatory cytokines (IL-6, TNF-α, CRP), and disrupts intercellular communication.
The core issue is that conventional medicine primarily targets the visible consequences of inflammation rather than its origin. Antiinflammatory drugs may suppress symptoms, but the underlying inflammatory terrain remains unchanged. This terrain is shaped by everyday factors: chronic stress, high allostatic load, autonomic nervous system dysregulation, constant insulin stimulation, oxidised omega-6 fats, dietary antinutrients, and impaired deep sleep. Biologically, inflammaging is measurable. Elevated hs- CRP, IL-6, TNF-α, altered neutrophil-to-lymphocyte ratios, mitochondrial DNA damage, and accelerated telomere shortening are consistently observed. Mitochondria play a pivotal role. Chronic inflammation reduces mitochondrial efficiency while increasing reactive oxygen species, creating a selfreinforcing loop of declining energy and escalating inflammation. This explains early fatigue, cognitive decline, and poor recovery long before disease onset. The gut represents another critical node. Increased intestinal permeability allows lipopolysaccharides (LPS) to enter circulation, triggering innate immune activation. Addressing inflammaging without restoring gut barrier integrity is fundamentally incomplete.
Personal protocol
My personal approach to inflammaging is never based on a single intervention, but on a progressive, biomarker-guided, and reversible strategy. In specific phases, I use injectable peptides (TB500, BPC157, GHK- Cu, Epitalon, etc…) applied in regenerative medicine for their role in inflammatory modulation, tissue repair, and mitochondrial signalling. These are used in short, targeted cycles with biological monitoring. In parallel, I rely on precision supplementation supporting oxidative balance, glycaemic stability, mitochondrial function, and autonomic regulation. In rare, advanced contexts, I have also explored plasma-based interventions, always within a medically supervised, experimental framework. These approaches never replace foundational pillars such as sleep, stress regulation, nutrition, and circadian alignment. The conclusion remains consistent: no advanced intervention compensates for an unresolved inflammatory terrain.
Chronic inflammation also disrupts insulin signalling. Each uncontrolled glucose spike acts as a microinflammatory stressor, contributing more to biological aging than total caloric intake alone. In women, this process is often amplified by hormonal fluctuations, higher cortisol sensitivity, mineral deficiencies, and mental load—yet most interventions remain derived from male physiology.
Silent inflammation is not an inevitable consequence of aging. It largely reflects a chronic mismatch between biology and modern life. Identifying and correcting this inflammatory terrain is one of the most powerful levers to slow biological aging.
Valérie Orsoni
Valérie Orsoni has been a biohacker since 1998, author of 55 books published in five languages, entrepreneur, and international speaker. Founder of valbiohacker.com, she has spent over 25 years exploring biological aging through science, data-driven measurement, and real experimentation.
